2025 Male Fertility Studies
FertileFacts lists all of the 2025 Male Fertility studies to date. We update this list frequently, so check back soon!
Partial progress in sexual and reproductive health and rights: the influence of sociocultural, behavioural, structural, and technological changes on epidemiological trends.
Summary: A thorough understanding of the driving factors behind global epidemiological trends in sexual and reproductive health-such as fluidity in gender and sexual identity, biomedical innovations in contraception and the treatment and prevention of HIV and other sexually transmitted in …
Read on PubMedMale reproductive and sexual health outcomes following intravesical therapy for non-muscle invasive bladder cancer.
Summary: While these therapies effectively reduce tumor recurrence and progression, their impact on male reproductive health remains underexplored. This review synthesizes current evidence on the reproductive effects of intravesical therapies in men with NMIBC. ...Genitourin …
Read on PubMedSalivary Testosterone, Age, and Adiposity Associations Among Shuar Males in Amazonian Ecuador Challenge Assumptions of "Normal" Testosterone Patterns.
Summary: OBJECTIVES: Adult male testosterone concentrations in high income countries often decrease with age and adiposity, a pattern typically viewed as "normal." However, testosterone is expected to be adaptively regulated within the range of resource constrained, high pathogen, …
Read on PubMedIs stress different in infertile women and men? A systematic review and meta-analysis.
Summary: BACKGROUND: Stress is gender-specific and differs between in infertile women and men Therefore, according to the importance of this issue, this systematic review and meta-analysis was conducted to investigate the difference in stress in infertile women and men. ...T …
Read on PubMedHome-insemination: the motivations and experiences of same-sex and gender diverse couples using self-insemination and known donors to conceive in Aotearoa New Zealand.
Summary: Donor conception that occurs outside of clinical fertility settings is understood to be increasingly common, yet research on this practice remains limited. ...While participants were parents of children conceived after the introduction of the Human Assisted Reproduc …
Read on PubMedCompound heterozygous REC114 variants in dizygotic twins causes meiotic arrest and non-obstructive azoospermia.
Summary: BACKGROUND: Meiosis is essential for gametogenesis and the maintenance of fertility. Central to this process is meiotic recombination, a mechanism that ensures accurate chromosome segregation and drives genetic diversity. ...This research offers new insights into the genet …
Read on PubMedComparison of urine and semen samples for HPV detection: a cross-sectional study in fertility clinic patients.
Summary: This study aimed to assess the correlation between HPV DNA detection in urine and semen samples from men attending a fertility clinic in Ecuador. This cross-sectional study included 106 sexually active male patients referred for semen analysis at the Ferti …
Read on PubMedEfficacy of Gonadotropin Therapy to Induce Spermatogenesis and Fertility in Men with Pathologic Gonadotropin Deficiency.
Summary: CONTEXT: Gonadotropin treatment to induce spermatogenesis for gonadotropin-deficient men is the only medically treatable cause of male infertility. However, time-dependent analyses of fertility outcomes in large cohorts are lacking. We evaluated the time to, …
Read on PubMedCognition of the association between sexual dysfunction and fertility.
Summary: BACKGROUND: While research has shown that sexual dysfunction does not impact fertility, public understanding of this relationship remains unclear. AIM: To investigate the relationship between public cognition of the association between sexual dysfunction and fertility …
Read on PubMedFirst in class monoclonal antibody potentiating human follicle stimulating hormone activity improves spermatogenesis in azoospermic rodent models.
Summary: METHODS: Potentiation of recombinant hFSH (rhFSH)-, human luteinizing hormone/chorionic gonadotropin (hLH/hCG)-, or human thyroid stimulating hormone (TSH)-mediated cyclic adenosine monophosphate (cAMP) induction in vitro was performed using HEK 293 cells overexpres …
Read on PubMedProteome of seminal plasma and sperm associated with sperm survival following cryopreservation in the Red Wolf (Canis rufus).
Summary: Understanding of the impacts of seminal plasma and sperm proteins on both animal and human fertility has expanded rapidly in the last decade. However, little is known about the reproductive proteomes of endangered species. ...
Read on PubMedEffects of Homocysteine Circulating Levels on Human Spontaneous Fertility and In Vitro Fertilization Outcomes: A Literature Review.
Summary: Background: Homocysteine (Hcy) plays a pivotal role in human reproduction, influencing gamete quality, embryo development, implantation, and pregnancy outcomes. ...The emerging picture is complex, as Hcy and its metabolites impact biomolecules and cellular processes in a t …
Read on PubMedHuman Testicular Tissue Digestion, Testicular Cell Selection, and Downstream Characterization for Reproductive Purposes: A Scoping Review.
Summary: Fertility preservation and restoration using cryo-banked prepubertal testicular tissue is a pivotal part of the childhood hematological cancer care pathway. ...In this review, mechanical dissociation/enzymatic digestion protocols applied to human testicular tissue, …
Read on PubMedTime to birth for spontaneous and ART births among infertile groups.
Summary: ART births occurred faster when pregnancy attempts were initiated in 2000-19 rather than 1987-99 (coeff = 0.536, [0.198; 0.873] for women, coeff = 0.487, [0.072; 0.902] for men), and when men and women tried to conceive for the first time at age 35-39 (coeff = 1.215 …
Read on PubMedAssociation Between Antibiotic Exposure and the Risk of Male Infertility: A Case-Control Study.
Summary: The study was a prospective case-control study involving 136 infertile men and 154 fertile men recruited from five hospitals in southern Nigeria. Semen analysis was carried out, while Liquid Chromatography Mass Spectrometry was used to assay for various antib …
Read on PubMedSIRT3 Mediates Coordination Between Energy Metabolism and SOD Activity in Melatonin-Enhanced Boar Sperm Motility.
Summary: Targeting SIRT3 represents a promising therapeutic strategy for improving boar fertility and may also provide insights for research into human male infertility....
Read on PubMedReproductive Dysfunction and Testicular Epigenetic Alterations in Male Rats with Experimental Amebiasis: Evaluation of SPATA6 Methylation and Therapeutic Outcomes.
Summary: This study investigated the effects of experimental amebiasis induced by Entamoeba histolytica and its treatment with metronidazole (MTZ) on the methylation status of the Spermatogenesis Associated 6 (SPATA6) gene and male reproductive function. Twenty-four adult male …
Read on PubMedEffect of isotretinoin on sperm quality in humans: an in vitro model.
Summary: OBJECTIVE: Isotretinoin is a retinoid widely used for severe acne, known for its teratogenicity, but with an unclear impact on male fertility and the risk of fetal exposure through semen. This study evaluated in vitro the effect of different concentrations of isotre …
Read on PubMedWhat Moves Men to Change? A Mixed-Methods Study on Facilitators and Barriers of Lifestyle Changes in Men Seeking Fertility Care.
Summary: BACKGROUND: An unhealthy lifestyle negatively affects male fertility. Despite this, men that are part of an infertile couple often fail to improve their lifestyle and evidence on influencing factors is limited. ...These results should inspire fertility …
Read on PubMedRetrospective evaluation of the use of non-human primates for fertility assessment of pharmaceuticals submitted for marketing approval in the EU.
Summary: During development, potential adverse effects of pharmaceuticals on male and female fertility are evaluated. Although non-human primates (NHP) can be an appropriate model for some pharmaceuticals, there are scientific, ethical and practical limitations. ...He …
Read on PubMedThe role of HLA-E polymorphism and soluble HLA-E isoform in recurrent reproductive failures and male infertility.
Summary: BACKGROUND: Human leukocyte antigen (HLA)-E as a non-classical HLA class I molecule interacting with NK and T cell receptors may activate or inhibit immune responses. ...CONCLUSIONS: HLA-E*0101 homozygosity and lower levels of soluble HLA-E in men's ejaculate are as …
Read on PubMedParental dietary patterns and assisted reproductive technology outcomes including embryo morphokinetics: rotterdam periconception cohort.
Summary: METHODS: From the ongoing Rotterdam periconception cohort, we included 149 women and 126 men attending a fertility outpatient clinic for ART treatment. Dietary intake was assessed using a validated self-reported food frequency questionnaire with implausible dietary …
Read on PubMedAssociations of In Utero Exposure to Racial Violence and Reproductive Development: The Bogalusa Heart Study.
Summary: Pubertal development was assessed using age at menarche for girls and Tanner staging at age 13 for boys (n = 1945) and girls (n = 1970). Fertility outcomes, including fertility issues and miscarriage, were obtained by self-report from the Bogalusa Babies study (2012 …
Read on PubMedBioactive metabolites from Paeonia lactiflora protect against heat-induced male infertility in Drosophila melanogaster by modulating Vasa: integrating in vivo and computational analyses.
Summary: This study investigates the potential of isolated compounds from Paeonia lactiflora to mitigate heat stress-induced male infertility in Drosophila melanogaster, with egg-hatching rates as a quantitative fertility indicator. Exposure to thermal stress (27.5 C) signif …
Read on PubMedFeminizing Adrenocortical Carcinoma in Men: A Rare Cause of Persistent Gynecomastia and a Contemporary Literature Review.
Summary: BACKGROUND: Feminizing adrenocortical tumors (FATs) are an exceedingly rare subset of adrenal neoplasms, typically affecting adult men and characterized by an excess of estrogen, suppressed gonadotropins, and gynecomastia. ...CASE PRESENTATION: We report the case of a 24-y …
Read on PubMedMulti-omics analysis of testis after long-term exposure to polystyrene nanoplastics reveals premature testicular aging and age-dependent damage in mice.
Summary: BACKGROUND: Nanoplastics (NPs) are emerging contaminants posing significant risks to human health due to their enhanced cellular penetration. NPs have been shown to damage human testes and epididymides, impairing male fertility. ...RESULTS: In this stu …
Read on PubMedTestosterone Therapy in Men in Their 40s: A Narrative Review of Indications, Outcomes, and Mid-Term Safety.
Summary: Late-onset testosterone deficiency in early middle-aged men (40-49 years) is increasingly recognized and is often associated with obesity, metabolic syndrome, and sleep apnea. Prevalence estimates suggest that 6%-12% of men in this age group have biochemically low t …
Read on PubMedReligion and Vasectomy Uptake Among Married Men in the USA.
Summary: Despite clear links between religious commitment, sexual behavior, and fertility, relatively little is known about religion's role in contraceptive practices, especially vasectomy uptake. ...However, even after controlling for these and other background factors, Hispanic C …
Read on PubMedThe Impact of Diabetes Mellitus-Related Oxidative Stress on Male Fertility: A Review.
Summary: Obesity and metabolic syndrome, common comorbidities in DM, amplify oxidative stress and further impair fertility potential. While seminal plasma contains enzymatic and non-enzymatic antioxidants, these defenses are often insufficient in diabetic men. ...This review …
Read on PubMedThe relationship between parent-child attachment and fertility intention: the mediating role of family resilience and the moderating role of gender moderating.
Summary: RESULTS: (1) Parent-child attachment (including its sub-dimensions: father attachment and mother attachment), family resilience (including its sub-dimensions: family beliefs and family strength), and fertility intention show significant positive correlations; (2) Total sco …
Read on PubMedImpact of sickle cell anaemia on reproductive health: a narrative review.
Summary: This review looks at how SCD can impact the ability of a person to have children and their overall sexual health. In both men and women, SCD can block blood flow, which can harm important organs needed to have children, like the testes in men and the ovaries in wome …
Read on PubMedBeyond borders and blockades: human trafficking risks among vulnerable Palestinian populations under occupation.
Summary: This article explores the nexus between political occupation, economic marginalization, and the risk of human trafficking in the occupied Palestinian territory (oPt). It argues that the ongoing Israeli occupation and blockade, particularly of Gaza and Area C of the West Ba …
Read on PubMedNo Evidence of Temporal Decline in Semen Parameters Over 17 Years Among Men Who Underwent Fertility Evaluation from Indian Southern States.
Summary: Over the past four decades, reports have emphasized the spatial and temporal trends in human semen quality and other markers of male reproductive health, which have sparked significant debate among fertility professionals. ...The study aimed to retrospectivel …
Read on PubMedElectromagnetic fields and oxidative stress: The link to the development of cancer, neurological diseases, and behavioral disorders.
Summary: Heisenberg's principle underlies normal aging and sets the limit to life expectancy. SOCIAL IMPLICATIONS: The human brain, particularly the structural and functional networks that support social communication, is highly vulnerable to oxidative stress associated with EMF ex …
Read on PubMedOral Toxicity Study of Silicon Dioxide Nanoparticles on Fertility and Early Embryonic Development in Mice.
Summary: SiO(2)NPs were administered once daily via oral gavage at doses of 0, 60, 250, and 1000 mg/kg during the pre-mating, mating, and early gestation periods. Endpoints related to fertility and early embryonic development were evaluated, including female fertility, tubal …
Read on PubMedEvaluating the Effect of Oxytocin and Zinc Sulphate on Reproductive Indices in Opiate-Addicted Men Receiving Methadone Maintenance Therapy: A Randomized, Double-Masked Clinical Trial.
Summary: Notably, oxytocin administration has demonstrated potential in influencing neurobehavioral changes related to drug abuse. Furthermore, the effect of zinc on male fertility has been established. This study aimed to assess the impact of combining oxytocin with zinc su …
Read on PubMedVariables Associated with Knowledge of the Fertile Window in Women and Men in Colombia and Ecuador.
Summary: RESULTS: Women were nearly twice as likely as men to demonstrate knowledge of the fertile window (odds ratio [OR] = 1.98; 95% confidence interval [CI]: 1.32-2.97). ...Participants with higher income (OR = 2.59; 95% CI: 1.54-4.35), fertility intentions (OR = 1 …
Read on PubMedSERINC4 is dispensable for male fertility and spermatogenesis in mice.
Summary: This study aimed to investigate the in vivo role of SERINC4 in spermatogenesis and male fertility using a Serinc4-knockout (KO) mouse model. METHODS: Single-cell RNA sequencing (scRNA-seq) data were analyzed to determine the expression pattern of SERINC4 in human …
Read on PubMedFactors Associated With Willingness to Undergo Bilateral Tubal Ligation Among Women Attending Antenatal and Family Clinics of UNIOSUN Teaching Hospital, Osogbo, Nigeria.
Summary: Interventions to improve BTL acceptance should prioritize couple-focused counselling, engage men in reproductive health decisions, and integrate BTL education into antenatal services....
Read on PubMedEvidence that declining human fecundity contributes to the fertility crisis.
Summary: Fertility rates have fallen to unprecedentedly low levels worldwide, reflecting a widespread fertility crisis. ...
Read on PubMedBreathing new life into male fertility: the potential of mitochondrial transplantation.
Summary: Male infertility affects about 7% of men worldwide. Along with this disease also comes stigma and taboo that overshadow its emotional and psychological impacts. Despite its widespread prevalence, many cases of male infertility remain idiopathic. This review i …
Read on PubMedThe role of testicular ultrasonography as a screening tool for testicular dysfunction in hypospadias.
Summary: CONCLUSION: Testicular parenchymal inhomogeneity was more common in men born with hypospadias and was associated with testicular, surgical and prenatal factors. ...
Read on PubMedSerum IgG1 and IgG3 antibodies to Chlamydia trachomatis Pgp3 and Hsp60 in men of subfertile couples.
Summary: PURPOSE: Our goal was to investigate IgG1 and IgG3 antibody responses to Chlamydia trachomatis proteins Pgp3 and Hsp60 in males of subfertile couples and to explore the association of these antibodies with semen parameters and male factor infertility. METHODS: Serum sample …
Read on PubMedEndoCompass project: research roadmap for reproductive and developmental endocrinology.
Summary: BACKGROUND: Endocrine science remains underrepresented in European Union research programs despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and the …
Read on PubMedEndoCompass project: research roadmap for endocrine causes and consequences of cancer.
Summary: BACKGROUND: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and t …
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