The Bottom Line
The Bottom Line: Seed offers an innovative, first-of-its-kind approach to probiotic and prebiotic supplements. The brand is rooted in cutting-edge science, focusing on how optimizing your microbiome can prevent and treat various health concerns. Seed’s VS-01™ Vaginal Synbiotic is the first probiotic suppository that’s been clinically validated to create an optimal vaginal microbiome, preventing disruptions and imbalances.
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SEED VS-01™
5 / 5 stars
- Multi-strain probiotic and prebiotic
- Vegan, cruelty-free, and free of artificial fragrances, preservatives, dyes,
- Tested for over 500 contaminants, including chemical residues, heavy metals, and 14 classes of allergens
- Buy Now
The Essentials
We’ve broken down the essentials to make it easy for you to learn about Seed VS-01™
| Details | |
| Key Ingredient | VS-01™ contains 3 live strains of L. crispatus, chosen for their genomic diversity and stability. |
| Disruptors of Vaginal Microbiome | Antibiotics, Hormonal changes, Stress, Dietary factors, Intimate hygiene products, Menstruation, Some contraceptives, cleansers, and prescriptions, Swimming |
| Unique Attribute | VS-01™ is the first and only vaginal synbiotic clinically validated to optimize the vaginal microbiome with 3 proprietary L. crispatus probiotic strains. |
| Approach | Seed addresses the source of imbalances, protecting against daily disruptions and optimizing the vaginal microbiome. |
| Price and Regimen | Month 1: Reset – $99 for a 2-month supply (establishes an optimal vaginal microbiome) Month 2+: Sustain – $39.99 per month (retains stability and protection) |
Pros and Cons
Pros | Cons |
| Formulated with 3 proprietary strains of L. crispatus, the most protective probiotic strain for the vaginal microbiome | More expensive than other vaginal probiotics |
| Slow-release delivery technology enhances exposure to the vaginal wall for better results than oral probiotics | Requires a subscription |
| Backed by extensive clinical research to ensure safety and effectiveness | |
| Offers a starter kit and maintenance protocol to establish and maintain an optimal microbiome | |
- Featured partner offer
- Shop with confidence
SEED VS-01™
5 / 5 stars
- Multi-strain probiotic and prebiotic
- Vegan, cruelty-free, and free of artificial fragrances, preservatives, dyes,
- Tested for over 500 contaminants, including chemical residues, heavy metals, and 14 classes of allergens
- Buy Now
The Science
Ok, so what does a Vagina Probiotic Do?
As a vaginal probiotic, VS-01™ is formulated to restore and maintain an optimal vaginal microbiome and vaginal pH. This helps protect against day-to-day disruptions and prevent imbalances that can lead to infection, like bacterial vaginosis (BV).
Let’s break down the ingredients in VS-01™ to help you better understand how a vaginal probiotic may benefit your wellness routine.
The Ingredients
| Key Ingredient | Details |
| L. Crispatus Probiotics Strains | VS-01™ contains 3 live, proprietary strains: LUCA103™, LUCA011™, LUCA009™. Chosen from Seed’s bank of over 600 strains. |
| Benefits of L. crispatus | Found to be effective against BV and candidiasis. Associated with reduced prevalence of reproductive disorders like bacterial vaginosis and preterm birth. |
| Prebiotics/Nutrient Complex | CST-1™ Nutrient Complex includes maltose, calcium lactate, glutamine, DiBasic magnesium citrate, and cysteine. These support the L. crispatus strains in the vaginal microbiome. |
| Other Ingredients | Plant-derived cellulose creates the suppository capsule. Magnesium stearate prevents ingredients from binding together. HPMC enhances stability and enables slow-release technology. |
The Seed difference
What sets Seed’s VS-01™ apart from other probiotics for vaginal health? It comes down to:
- Vaginal Microbiome Specificity: The vaginal microbiome is unique and distinct from other microbiomes in the body. Compared to microbiomes in the gut and mouth, which thrive with increased diversity, research indicates that the vaginal microbiome thrives with fewer bacterial strains and higher amounts of L. crispatus. Seed considered what makes the vaginal microbiome different by formulating VS-01™ with three strains of L. crispatus.
- Delivery Method: Seed VS-01™ is a vaginal suppository tablet with an extended-release profile, unlike oral probiotics that must navigate the gastrointestinal tract. The slow-release delivery technology was created to improve exposure to the vaginal wall and, according to Seed’s clinical trial, is more effective than other vaginal and oral probiotic forms.
- Prevalence of Imbalance: According to Seed Health, 9 out of 10 women have an imbalanced vaginal microbiome, increasing their susceptibility to infections such as UTIs, bacterial vaginosis, and yeast infections. With a monthly subscription model, Seed provides ongoing protection against daily disruptions.
- Current Treatments: Antibiotics are commonly used to treat vaginal infections like bacterial vaginosis. But, by eradicating good and bad bacterial strains, antibiotics can disrupt the vaginal microbiome, often leading to recurring infections. By preserving an optimal vaginal microbiome, VS-01™ offsets this concern while potentially reducing the need for antibiotics to treat vaginal infections.
- Proprietary Strains: Not all strains of L. crispatus are equally protective. VS-01™ uses three proprietary strains selected from over 600 candidates for their superior efficacy in maintaining pH balance and promoting vaginal health stability.
Side Effects
With Seed’s robust safety testing protocol, VS-01™ underwent clinical and preclinical testing to ensure safety, along with extensive third-party testing for contaminants, heavy metals, impurities, and all classes of allergens. Additionally, Seed uses an FDA-recognized tissue model to test for safety and vaginal biocompatibility.
However, especially when you first start using VS-01™, you may experience temporary side effects as your body acclimates to the formula, including:
- Increased vaginal discharge
- Mild to moderate vaginal irritation
- Pelvic cramps
- Abdominal discomfort
It’s also worth noting that the VS-01™ includes mannitol, which can cause yeast infections for some. But, for me, the benefits of the synbiotic formula outweighed this risk.
These side effects vary from person to person and generally resolve quickly. In Seed’s clinical trial, the highest side effect occurrence affected around 2.5% of participants, although these effects were comparable to those experienced by the placebo group.
- Featured partner offer
- Shop with confidence
SEED VS-01™
5 / 5 stars
- Multi-strain probiotic and prebiotic
- Vegan, cruelty-free, and free of artificial fragrances, preservatives, dyes,
- Tested for over 500 contaminants, including chemical residues, heavy metals, and 14 classes of allergens
- Buy Now
Our Recommendation
Why I Recommend Seed VS-01™ Vaginal Probiotic
I’ve always prioritized my vaginal health, especially with my active lifestyle which includes frequent workouts and travel. Having personally struggled with irritation, itching, and odor after sex, maintaining my vaginal health became a top priority, especially as my partner and I are trying to conceive.
Using Seed VS-01™ has transformed my approach to personal wellness. After completing the Month 1 Reset, which established a healthy microbiome, the Sustain kit has helped maintain my vaginal microbiome’s pH balance, preventing those pesky infections I used to worry about.
I found Seed VS-01™ to be a game-changer for several reasons:
- Effective Relief from Common Issues
- The VS-01™ suppository significantly helped with my recurrent yeast infections and bacterial vaginosis (BV). This was a relief after trying multiple other products with little success. Recent studies have shown that the presence of vaginal lactobacilli, particularly L crispatus, is strongly correlated with the absence of bacterial vaginosis.
- Research Note: It’s important to consider the role other factors, like estrogen levels, diet, and other treatments, can play in vaginal infections. Estrogen levels can influence vaginal health and the occurrence of yeast infections for some users. The VS-01™ synbiotic includes L. crispatus strains that can help maintain vaginal pH balance and overall health.
- Convenient and Thoughtful Delivery
- VS-01’s delivery technology is highly convenient. The suppository’s unique slow-release delivery technology ensures that the beneficial strains reach deep into the vaginal walls, where they’re needed most. The doses are spaced at seven-day intervals, allowing me to use them seamlessly around my menstrual cycle and integrate them easily into my routine. This level of convenience is essential for maintaining consistent vaginal health care.
- Rigorous Testing and Safety
- What truly sets VS-01™ apart is its rigorous testing. Seed conducts extensive testing for 14 classes of allergens, including gluten, nuts, and soy, and over 500 contaminants, including chemical residues and heavy metals like BPAs. This gave me peace of mind in knowing that I was using a safe and thoroughly vetted product.
- Featured partner offer
- Shop with confidence
SEED VS-01™
5 / 5 stars
- Multi-strain probiotic and prebiotic
- Vegan, cruelty-free, and free of artificial fragrances, preservatives, dyes,
- Tested for over 500 contaminants, including chemical residues, heavy metals, and 14 classes of allergens
- Buy Now
The Competition
Seed vs. Love Wellness vs. Good Clean Love
We compared Seed Health to alternative vaginal probiotic suppositories, including Love Wellness (Flora Power) and Good Clean Love (BiopHresh), to help you better understand which brand will work best for your needs.
| Seed Health vs. Love Wellness vs. Good Clean Love |  |  |  |
| Price | $99 for 2-months starter kit $39.99/month thereafter | $17 | $17.99 |
| Probiotic blend | 3 proprietary live L. crispatus probiotic strains | Lactobacillus acidophilus LA02, Lactobacillus crispatus LCR01, Lactobacillus gasseri LGS06, Limosilactobacillus fermentum LF08, Lactiplantibacillus plantarum LP01, Lacticaseibacillus rhamnosus LR06, Ligilactobacillus salivarius CRL1328 | Lactobacillus fermentum LF61, Lactobacillus acidophilus LA85, Lactobacillus plantarumLp90 |
| Dosage | 850 mg | 🟡 | 466 mg |
| Applicator included? | ✅ | ✅ | ❌ |
| Slow-release delivery technology? | ✅ | ❌ | ❌ |
| Rigorous safety testing? | ✅ | ✅ | ✅ |
| In-house clinical research? | ✅ | ❌ | ❌ |
| Major allergen-free? | ✅ | ✅ | ✅ |
| Parabens free? | ✅ | ✅ | ✅ |
| Website | Seed Health | Good Clean Love | Love Wellness |
What makes Seed different?
What sets Seed’s VS-01™ apart from other probiotics for vaginal health? It comes down to:
- Vaginal Microbiome Specificity: The vaginal microbiome is unique and distinct from other microbiomes in the body. Compared to microbiomes in the gut and mouth, which thrive with increased diversity, research indicates that the vaginal microbiome thrives with fewer bacterial strains and higher amounts of L. crispatus. Seed considered what makes the vaginal microbiome different by formulating VS-01™ with three strains of L. crispatus.
- Delivery Method: Seed VS-01™ is a vaginal suppository tablet with an extended-release profile, unlike oral probiotics that must navigate the gastrointestinal tract. The slow-release delivery technology was created to improve exposure to the vaginal wall and, according to Seed’s clinical trial, is more effective than other vaginal and oral probiotic forms.
- Prevalence of Imbalance: According to Seed Health, 9 out of 10 women have an imbalanced vaginal microbiome, increasing their susceptibility to infections such as UTIs, bacterial vaginosis, and yeast infections. With a monthly subscription model, Seed provides ongoing protection against daily disruptions.
- Current Treatments: Antibiotics are commonly used to treat vaginal infections like bacterial vaginosis. But, by eradicating good and bad bacterial strains, antibiotics can disrupt the vaginal microbiome, often leading to recurring infections. By preserving an optimal vaginal microbiome, VS-01™ offsets this concern while potentially reducing the need for antibiotics to treat vaginal infections.
- Proprietary Strains: Not all strains of L. crispatus are equally protective. VS-01™ uses three proprietary strains selected from over 600 candidates for their superior efficacy in maintaining pH balance and promoting vaginal health stability.
- Featured partner offer
- Shop with confidence
SEED VS-01™
5 / 5 stars
- Multi-strain probiotic and prebiotic
- Vegan, cruelty-free, and free of artificial fragrances, preservatives, dyes,
- Tested for over 500 contaminants, including chemical residues, heavy metals, and 14 classes of allergens
- Buy Now
The Verdict
Overall, Seed’s VS-01™ vaginal synbiotic is ideal for people looking to improve their vaginal health, become more resilient against daily disruptions, and prevent infections, like BV. With an unparalleled degree of scientific research and safety testing, Seed is revolutionizing the role of probiotics in women’s health. Additionally, with 3 proprietary strains of L. crispatus, you simply can’t find this formulation from other brands.
In my experience, VS-01™ made it ultra-simple to prevent infections and disruptions caused by my day-to-day routine. From intense exercise to intimate settings, this probiotic offered consistent protection against imbalances so that I didn’t have to worry about itching, inflammation, or discomfort. VS-01™ is also a great way to complement your treatment plan for recurring vaginal infections, although you should talk to your doctor before combining medications and supplements.
Although Seed’s vaginal synbiotic is more expensive than other probiotic suppositories for vaginal health, its foundation of scientific research and proprietary strains make up for the price disparity.
- Featured partner offer
- Shop with confidence
SEED VS-01™
5 / 5 stars
- Multi-strain probiotic and prebiotic
- Vegan, cruelty-free, and free of artificial fragrances, preservatives, dyes,
- Tested for over 500 contaminants, including chemical residues, heavy metals, and 14 classes of allergens
- Buy Now
FAQs
Can probiotics affect your period?
Probiotics may benefit your period by improving certain PMS symptoms. One study found that probiotics improved mental health and reduced NSAID use in individuals with primary dysmenorrhea. Additionally, probiotics may help prevent BV infections during or after your period, as BV is more common around menstruation.
What are the side effects of probiotics for women's pH balance?
Vaginal probiotics for women’s pH balance may cause temporary side effects, including increased vaginal discharge, mild to moderate vaginal irritation, pelvic cramps, and abdominal discomfort.
How long does a vaginal suppository take to work?
A vaginal suppository may take up to 30 minutes to dissolve. While results can vary, it can take 1 to 2 months to restore a healthy vaginal microbiome with the VS-01™ suppository.
Can I pee after inserting a suppository?
You can pee after inserting a vaginal suppository, as urine comes from the urethra, not the vagina.
